request = HTTPXRequest(
    connection_pool_size=50,
    read_timeout=30,
    write_timeout=30,
    connect_timeout=30,
    pool_timeout=30,
    media_write_timeout=300,
)
application = (
    ApplicationBuilder()
    .defaults(defaults=my_defaults)
    .token(token=BOT_TOKEN)
    .base_url("http://localhost:8081/bot")
    .base_file_url("http://localhost:8081/file/bot")
    .local_mode(True)